- New research looking at more than 39,000 UK biobank participants has found that those with higher heart pressure estimated by magnetic resonance imaging (MRI) were five times more likely to develop heart failure
- The main risk factors discovered for increased heart pressure include age over 70, high blood pressure, obesity, alcohol consumption and male gender.
- Breakthrough from the University of East Anglia and Queen Mary University of London suggests cardiac MRI could potentially replace invasive diagnostic tests
Peer Review – Observational Study – People
MRI scans could replace invasive heart tests, as new research shows they can reliably estimate pressures inside the heart to predict whether a patient will develop heart failure.
Research from the University of East Anglia (UEA) and Queen Mary University of London has also identified key risk factors for increased pressure within the heart, which leads to heart failure.
These risk factors include being over 70 years old, having high blood pressure, being obese, drinking alcohol, and being male.
Co-lead author Dr Pankaj Garg, from UEA’s Norwich Medical School, said: “Heart failure is a lethal condition resulting from increased blood pressures. One of the most significant findings of this study is that MRI-derived blood pressure measurements can reliably predict whether an individual will develop heart failure.
“This finding suggests that cardiac MRI could potentially replace invasive diagnostic tests. Participants with higher heart pressure measured by MRI had a fivefold increased risk of developing heart failure over six years.”
Previous pioneering research involving UEA and the Universities of Sheffield and Leeds has shown that cardiac MRI techniques can estimate pressure in the heart and are linked to symptoms and signs of heart failure.
However, to date, it is not known whether pressures derived from cardiac magnetic resonance imaging can predict the risk of heart failure in the general population.
Analyzing data from more than 39,000 UK Biobank participants, this latest research demonstrates that blood pressure changes detected by MRI can identify heart failure risk without invasive procedures.
Co-lead author Dr Nay Aung, from the William Harvey Research Institute at Queen Mary University of London, said: “In addition, we identified the main risk factors for developing high heart pressure: age over 70, high blood pressure, obesity, alcohol consumption and male gender.
“By combining these factors, we have developed a model to predict an individual’s risk of heart failure. This advance enables prevention, early detection and treatment of heart failure, which could save many lives.”
A cardiac MRI is a type of scan that uses powerful magnets and radio waves to create detailed images of the heart. Unlike X-rays or CT scans, it doesn’t use harmful radiation.
In this research paper, both teams analyzed cardiac MRI data from 39,000 UK biobank participants using artificial intelligence techniques and estimated the pressure inside the heart. They then assessed each individual’s risk factors and their chances of developing heart failure in the future over a six-year follow-up period.
The research was co-led by the University of East Anglia in partnership with Queen Mary University of London. Other contributions were made by St Bartholomew’s Hospital in London, Norfolk and Norwich University Hospitals, the universities of Leeds and Sheffield, Health Data Research UK and the Alan Turing Institute.
The UK Biobank is a large-scale biomedical database and research resource containing de-identified genetic, lifestyle and health information and biological samples from half a million UK participants.
The work was supported by the National Institute for Health and Care Research (NIHR) and the Wellcome Trust.
‘Risk factors for increased left ventricular filling pressure by cardiovascular magnetic resonance imaging: prognostic insights’ is published in European Society of Cardiology Heart Failure.
Newspaper
e-Journal of Cardiology Practice
Research Method
Observational study
Research Subject
People
Article title
Risk factors for increased left ventricular filling pressure by cardiovascular magnetic resonance imaging: Prognostic insights’
Article publication date
12-Aug-2024
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